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1

Imatinib mesylate for children with dermatofibrosarcoma protuberans (DFSP)

Saskia L.M. Gooskens, Arnold P. Oranje, Leon N.A. van Adrichem, Flora B. de Waard-van der Spek, Jan C. den Hollander, Cees P. van de Ven, Marry M. van den Heuvel-Eibrink

Journal:

Pediatric Blood & Cancer

Year:

2010

Language:

english

File:

PDF, 173 KB

english, 2010

2

Type I diabetes: a role for tissue factor in pancreatic islet transplantation?

Maikel P Peppelenbosch, C Arnold Spek

Journal:

Year:

2002

Language:

english

File:

PDF, 306 KB

english, 2002

3

The proactive wet-wrap method with diluted corticosteroids versus emollients in children with atopic dermatitis: A prospective, randomized, double-blind, placebo-controlled trial

Janmohamed, Sherief R., Oranje, Arnold P., Devillers, Arjan C., Rizopoulos, Dimitris, van Praag, Marinus C.G., Van Gysel, Dirk, Goeteyn, Marleen, de Waard-van der Spek, Flora B.

Journal:

Journal of the American Academy of Dermatology

Year:

2014

Language:

english

File:

PDF, 395 KB

english, 2014

4

Pharmacological PAR-1 inhibition reduces blood glucose levels but does not improve kidney function in experimental type 2 diabetic nephropathy

Waasdorp, Maaike, Florquin, Sandrine, Duitman, JanWillem, Spek, C. Arnold

Journal:

The FASEB Journal

Year:

2019

Language:

english

File:

PDF, 1.37 MB

english, 2019

5

Hedgehog: an unusual signal transducer

Maarten F. Bijlsma, C. Arnold Spek, Maikel P. Peppelenbosch

Journal:

Year:

2004

Language:

english

File:

PDF, 186 KB

english, 2004

6

PTX3 predicts severe disease in febrile patients at the emergency department

Martijn D. de Kruif, Maarten Limper, Karlien Sierhuis, Jiri F.P. Wagenaar, C. Arnold Spek, Cecilia Garlanda, Alessia Cotena, Alberto Mantovani, Hugo ten Cate, Pieter H. Reitsma, Eric C.M. van Gorp

Journal:

Journal of Infection

Year:

2010

Language:

english

File:

PDF, 180 KB

english, 2010

7

Does B-mode common carotid artery intima-media thickness differ from M-model?

Luc M. Van Bortel, Floris H. Vanmolkot, Janneke J. van der Heijden-Spek, Marsel Bregu, Jan A. Staessen, Arnold P. Hoeks

Journal:

Ultrasound in Medicine & Biology

Year:

2001

Language:

english

File:

PDF, 52 KB

english, 2001

8

Soluble E-selectin and soluble ICAM-1 levels as markers of the activity of atopic dermatitis in children

Albert Wolkerstorfer, Huub F. J. Savelkoul, Flora B. De Waard van der Spek, Herman J. Neijens, Tim van Meurs, Arnold P. Oranje

Journal:

Pediatric Allergy and Immunology

Year:

2003

Language:

english

File:

PDF, 100 KB

english, 2003

9

Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction

Sjoukje H Slofstra, Hugo ten Cate, C Arnold Spek

Journal:

Thrombosis Journal

Year:

2006

Language:

english

File:

PDF, 655 KB

english, 2006

10

Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir

Eefje Jong, Joost CM Meijers, Eric CM van Gorp, C Arnold Spek, Jan W Mulder

Journal:

AIDS Research and Therapy

Year:

2010

Language:

english

File:

PDF, 417 KB

english, 2010

11

Promoter analysis of the auxin-regulated tobacco glutathioneS-transferase genesNt103-1andNt103-35

Frans Droog, Arnold Spek, Annemieke Kooy, Arthur Ruyter, Harry Hoge, Kees Libbenga, Paul Hooykaas, Bert Zaal

Journal:

Plant Molecular Biology

Year:

1995

Language:

english

File:

PDF, 1.48 MB

english, 1995

12

Acute and subacute effects of nicorandil and isosorbide dinitrate on vessel wall properties of large arteries and hemodynamics in healthy volunteers

Mirian J. Kool, Janneke J. Spek, Harry A. Struyker Boudier, Arnold P. Hoeks, Robert S. Reneman, René H. Herwaarden, Luc M. Bortel

Journal:

Cardiovascular Drugs and Therapy

Year:

1995

Language:

english

File:

PDF, 754 KB

english, 1995

13

Identification of Evolutionarily Invariant Sequences in the Protein C Gene Promoter

C. Arnold Spek, Rogier M. Bertina, Pieter H. Reitsma

Journal:

Journal of Molecular Evolution

Year:

1998

Language:

english

File:

PDF, 937 KB

english, 1998

14

Consequence of functionalNod2andTlr4mutations on gene transcription in Crohn’s disease patients

Henri Braat, Pieter Stokkers, Tijmen Hommes, Danny Cohn, Esther Vogels, Inge Pronk, Arnold Spek, Antoine van Kampen, Sander van Deventer, Maikel Peppelenbosch, Daan Hommes

Journal:

Journal of Molecular Medicine

Year:

2005

Language:

english

File:

PDF, 188 KB

english, 2005

15

Functional thrombomodulin deficiency causes enhanced thrombus growth in a murine model of carotid artery thrombosis

Janine Dörffler-Melly, Martijn Kruif, LotharA. Schwarte, RendrikF. Franco, Sandrine Florquin, C.Arnold Spek, Can Ince, PieterH. Reitsma, Hugo Cate

Journal:

Basic Research in Cardiology

Year:

2003

Language:

english

File:

PDF, 140 KB

english, 2003

16

Differential effects of anticoagulants on tumor development of mouse cancer cell lines B16, K1735 and CT26 in lung

Tatjana M. H. Niers, Lois W. Brüggemann, Clara P. W. Klerk, Femke J. M. Muller, Tessa Buckle, Pieter H. Reitsma, Dick J. Richel, C. Arnold Spek, Olaf Van Tellingen, Cornelis J. F. Van Noorden

Journal:

Clinical and Experimental Metastasis

Year:

2009

Language:

english

File:

PDF, 348 KB

english, 2009

17

A mechanism for thrombin-dependent lung metastasis in patients with osteosarcoma

Keren Borensztajn, Hella Aberson, Angelique P. Groot, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

British Journal of Haematology

Year:

2009

Language:

english

File:

PDF, 119 KB

english, 2009

18

Food-induced contact urticaria syndrome (CUS) in young children with atopic dermatitis: practical consequences

Arnold P. Oranje, Flora B. de Waard-van der Spek, Lianne van Oostende, Roland S.R. Aarsen, Albert W. van Toorenenbergen, Paul H. Dieges

Journal:

Journal of the European Academy of Dermatology and Venereology

Year:

1994

Language:

english

File:

PDF, 2.40 MB

english, 1994

19

Purpura caused by Emla® is of toxic origin

Flora B. de Waard-van der Spek, Arnold P. Oranje

Journal:

Contact Dermatitis

Year:

1997

File:

PDF, 406 KB

1997

20

Contact dermatitis

Flora B. De Waard-van der Spek, Arjan C. A. Devillers, Arnold P. Oranje

Journal:

Contact Dermatitis

Year:

2008

Language:

english

File:

PDF, 41 KB

english, 2008

21

Coagulation factors VIIa and Xa inhibit apoptosis and anoikis

Versteeg, Henri H, Arnold Spek, C, Richel, Dick J, Peppelenbosch, Maikel P

Journal:

Year:

2004

Language:

english

File:

PDF, 218 KB

english, 2004

22

Treatment with an Anti-CD14 Monoclonal Antibody Delays and Inhibits Lipopolysaccharide-Induced Gene Expression in Humansin Vivo

C. Arnold Spek, Annelies Verbon, Hella Aberson, John P. Pribble, Cathal J. McElgunn, Terence Turner, Tim Axtelle, Jan Schouten, Tom van der Poll, Pieter H. Reitsma

Journal:

Journal of Clinical Immunology

Year:

2003

Language:

english

File:

PDF, 91 KB

english, 2003

23

Leukotriene Synthesis Is Required for Hedgehog-Dependent Neurite Projection in Neuralized Embryoid Bodies but Not for Motor Neuron Differentiation

Maarten F. Bijlsma, Maikel P. Peppelenbosch, C. Arnold Spek, Henk Roelink

Journal:

Year:

2008

Language:

english

File:

PDF, 995 KB

english, 2008

24

FXa-induced intracellular signaling links coagulation to neoangiogenesis: Potential implications for fibrosis

Keren Borensztajn, Hella Aberson, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2009

Language:

english

File:

PDF, 365 KB

english, 2009

25

Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites

Maarten F. Bijlsma, Keren S. Borensztajn, Henk Roelink, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Cellular Signalling

Year:

2007

Language:

english

File:

PDF, 815 KB

english, 2007

26

Extensive cerebral infarction in the newborn due to incontinentia pigmenti

Femke Maingay-de Groof, Maarten H. Lequin, Daniella W. Roofthooft, Arnold P. Oranje, Irenaeus F. de Coo, Levinus A. Bok, Peter J. van der Spek, Grazia M. Mancini, Paul P. Govaert

Journal:

European Journal of Paediatric Neurology

Year:

2008

Language:

english

File:

PDF, 563 KB

english, 2008

27

Hedgehog Turns Lipoproteins Into Janus-Faced Particles

Maarten F. Bijlsma, C. Arnold Spek, Maikel P. Peppelenbosch

Journal:

Trends in Cardiovascular Medicine

Year:

2006

Language:

english

File:

PDF, 148 KB

english, 2006

28

Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation

Keren S. Borensztajn, Maarten F. Bijlsma, Angelique P. Groot, Lois W. Brüggemann, Henri H. Versteeg, Pieter H. Reitsma, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Experimental Cell Research

Year:

2007

Language:

english

File:

PDF, 1.24 MB

english, 2007

29

Type-I Protein-C Deficiency Caused by Disruption of a Hepatocyte Nuclear Factor (HNF)-6/HNF-1 Binding Site in the Human Protein-C Gene Promoter

Arnold Spek, Pieter Reitsma

Journal:

Trends in Cardiovascular Medicine

Year:

1999

Language:

english

File:

PDF, 357 KB

english, 1999

30

Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders

Lois W. Brüggemann, Henri H. Versteeg, Tatjana M. Niers, Pieter H. Reitsma, C. Arnold Spek

Journal:

Journal of Cellular and Molecular Medicine

Year:

2008

Language:

english

File:

PDF, 2.88 MB

english, 2008

31

Hypoxia induces a hedgehog response mediated by HIF-1α

Maarten F. Bijlsma, Angelique P. Groot, Jeremiah P. Oduro, Rutger J. Franken, Saskia H. H. F. Schoenmakers, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Journal of Cellular and Molecular Medicine

Year:

2009

Language:

english

File:

PDF, 779 KB

english, 2009

32

The coagulation factor Xa/protease activated receptor-2 axis in the progression of liver fibrosis: a multifaceted paradigm

Keren Borensztajn, Jan H. Von Der Thüsen, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Journal of Cellular and Molecular Medicine

Year:

2010

Language:

english

File:

PDF, 719 KB

english, 2010

33

EMLA Cream: An Improved Local Anesthetic. Review of Current Literature

Flora B. De Waard-van der Spek, Gerdien M. Van Den Berg, Arnold P. Oranje

Journal:

Pediatric Dermatology

Year:

1992

Language:

english

File:

PDF, 958 KB

english, 1992

34

Genetic Risk Factors for Venous Thrombosis

C.Arnold Spek, Pieter H. Reitsma

Journal:

Molecular Genetics and Metabolism

Year:

2000

Language:

english

File:

PDF, 74 KB

english, 2000

35

C-Reactive Protein Elicits White Blood Cell Activation in Humans

Radjesh J. Bisoendial, Rakesh S. Birjmohun, Fatima Akdim, Cornelis van ‘t Veer, C. Arnold Spek, Daniel Hartman, Els R. de Groot, Danute M. Bankaitis-Davis, John J.P. Kastelein, Erik S.G. Stroes

Journal:

The American Journal of Medicine

Year:

2009

Language:

english

File:

PDF, 549 KB

english, 2009

36

Blood cell-derived tissue factor influences host response during murine endotoxemia

Saskia H.H.F Schoenmakers, Angelique P Groot, Sandrine Florquin, Pieter H Reitsma, C.Arnold Spek

Journal:

Blood Cells, Molecules, and Diseases

Year:

2004

Language:

english

File:

PDF, 177 KB

english, 2004

37

Blood coagulation factors as inflammatory mediators

Saskia H.H.F Schoenmakers, Pieter H. Reitsma, C. Arnold Spek

Journal:

Blood Cells, Molecules, and Diseases

Year:

2005

Language:

english

File:

PDF, 324 KB

english, 2005

38

(Pro-)vitamin D as treatment option for hedgehog-related malignancies

Maarten F. Bijlsma, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Medical Hypotheses

Year:

2008

Language:

english

File:

PDF, 40 KB

english, 2008

39

Signal transduction induced by activated protein C: no role in protection against sepsis?

Sjoukje H. Slofstra, Hugo ten Cate, C. Arnold Spek

Journal:

Trends in Molecular Medicine

Year:

2006

Language:

english

File:

PDF, 451 KB

english, 2006

40

Factor Xa: at the crossroads between coagulation and signaling in physiology and disease

Keren Borensztajn, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Trends in Molecular Medicine

Year:

2008

Language:

english

File:

PDF, 1.18 MB

english, 2008

41

Characterization of the intracellular signalling capacity of natural FXa mutants with reduced pro-coagulant activity

Monia Monti, Keren S. Borensztajn, Mirko Pinotti, Alessandro Canella, Alessio Branchini, Giovanna Marchetti, Pieter H. Reitsma, Francesco Bernardi, C. Arnold Spek

Journal:

Thrombosis Research

Year:

2009

Language:

english

File:

PDF, 484 KB

english, 2009

42

Coagulation Factor Xa inhibits cancer cell migration via Protease-activated receptor-1 activation

Keren Borensztajn, Maarten F. Bijlsma, Pieter H. Reitsma, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Thrombosis Research

Year:

2009

Language:

english

File:

PDF, 425 KB

english, 2009

43

Prophylactic plasma levels of the low molecular weight heparin nadroparin does not affect colon cancer tumor development in mouse liver

Clara P.W. Klerk, Tatjana M.H. Niers, Lois W. Brüggemann, Susanne M. Smorenburg, Dick J. Richel, C. Arnold Spek, Cornelis J.F. Van Noorden

Journal:

Thrombosis Research

Year:

2010

Language:

english

File:

PDF, 695 KB

english, 2010

44

Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation

Keren Borensztajn, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Thrombosis Research

Year:

2010

Language:

english

File:

PDF, 339 KB

english, 2010

45

Coagulation factor Xa signaling: the link between coagulation and inflammatory bowel disease?

Keren Borensztajn, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Trends in Pharmacological Sciences

Year:

2009

Language:

english

File:

PDF, 862 KB

english, 2009

46

The role of activated protein C in cancer progression

Geerte L. van Sluis, Harry R. Büller, C. Arnold Spek

Journal:

Thrombosis Research

Year:

2010

Language:

english

File:

PDF, 241 KB

english, 2010

47

Experimental and clinical effects of anticoagulants on cancer progression

Cornelis J.F. Van Noorden, Geerte L. van Sluis, C. Arnold Spek

Journal:

Thrombosis Research

Year:

2010

Language:

english

File:

PDF, 96 KB

english, 2010

48

The protein C pathway in cancer metastasis

C. Arnold Spek, Valder R. Arruda

Journal:

Thrombosis Research

Year:

2012

Language:

english

File:

PDF, 428 KB

english, 2012

49

Prilocaine/lidocaine patch as a local premedication for skin biopsy in children

Flora B. de Waard-van der Spek, Paul G.H. Mulder, Arnold P. Oranje

Journal:

Journal of the American Academy of Dermatology

Year:

1997

Language:

english

File:

PDF, 347 KB

english, 1997

50

Factor Xa Stimulates Proinflammatory and Profibrotic Responses in Fibroblasts via Protease-Activated Receptor-2 Activation

Keren Borensztajn, Jurriën Stiekema, Sebastiaan Nijmeijer, Pieter H. Reitsma, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

The American Journal of Pathology

Year:

2008

Language:

english

File:

PDF, 965 KB

english, 2008

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